plaguey s likely to spread and cause an epidemic disease plaguey fevers s causing irritation or annoyance a plaguey newfangled safety catch r in a disagreeable manner it's so plaguey cold! Usage(s) There he met an Englishwoman with a past as plaguey as his own and shared an island with her for three idyllic months. Along with the plaguey conscience came an equally debilitating ulcer. Synonym(s) pestilent pestilential pestiferous annoying bothersome galling irritating nettlesome pesky pestering plaguy teasing vexatious vexing plaguily