Prostacyclin analogs and PDE 5 inhibitors synergistically stimulate ATP release from human RBCs Prostacyclin (PGI2) and phosphodiesterase 5 (PDE5) inhibitors are vasodilators used in the treatment of pulmonary arterial hypertension (PAH). Although these drugs stimulate vascular dilation directly, erythrocytes also express the PGI2 receptor (IPR) and contain PDE5. PDE5 inhibitors potentiate IPR-mediated release of the potent vasodilator, adenosine triphosphate from erythrocytes. These ...
Sept. 20, 2013 - Science Daily
Paul Stamets in E/The Environmental Magazine Habitats have immune systems, just like people. And in order to potentiate the host defense of the habitat's immune systems, we have to invest in biodiversity,says Stamets. "So looking at the old growth forest now, the economic cost of a...