malignance n (medicine) a malignant state; progressive and resistant to treatment and tending to cause death n quality of being disposed to evil; intense ill will Usage(s) Although celebrity is as old as society, Schickel believes that its new malignance results from the rise of communications technology. The removal of the Italian dictator was, in a sense, preliminary surgery on the malignance still afflicting mankind. Its story, like all children's tales, is elementary malignance v. Synonym(s) malignancy malignity Antonym(s) benignity benignancy