Definition of alienate | Bee Dictionary of English

v arouse hostility or indifference in where there had formerly been love, affection, or friendliness
She alienated her friends when she became fanatically religious
v transfer property or ownership
v make withdrawn or isolated or emotionally dissociated
the boring work alienated his employees

Graham knew that he would alienate some co-believers, but they were people he was happy to alienate.
Questions over how long such an alliance could survive and how badly it would alienate Olmert's other coalition partners have dominated the media here for weeks.
I'm sure they can alienate Hispanics on a wide range of issues besides just immigration.

Republican-led House passes bill restricting abortion
By Rachelle Younglai WASHINGTON (Reuters) - The Republican-controlled House of Representatives on Tuesday passed legislation severely restricting abortions, a move that could alienate women from the conservative party. The bill would ban abortions 20 weeks after fertilization occurs, a time when a fetus begins to feel pain, Republicans said. The legislation makes exceptions for victims of rape ...
June 19, 2013 - Reuters via Yahoo! News
1 Player Seattle Mariners Fans Are Getting Absolutely Fed Up With
There have been a lot of low moments for the Seattle Mariners this season, many of which have continued to alienate an already angry fanbase. From disappointing seasons to never living up to expectations, the Mariners have been very difficult to love at times. But which player has truly worn out his welcome with the Mariners? One can make the argument in favor of Franklin Gutierrez. After ...
June 16, 2013 - Bleacher Report

Fidel Castro in International Herald Tribune
There has been a worldwide resurgence of the ideology of Islamic extremism. One of the results of this has been to further alienate the young from the nation in which they were growing up and also to turn already separate communities into 'no-go'... Michael Nazir-Ali http://www.google.com/url?q=http://en.wikipedia.org/wiki/Michael_Nazir-Ali&source=dictionary&usg=AFQjCNHEOvG-BsOJjGcxCGpqzSwoPDqDPA International Herald Tribune http://www.google.com/url?q=http://www.iht.com/articles/ap/2008/01/06/news/Britain-Islam.php&source=dictionary&usg=AFQjCNH-dFz-7X6t5qzxsjy73gb0Mp_wPQ Jan 5, 2008 2685 3709 alienate I enjoyed observing the embarrassing position of all the presidential candidates in the United States. One by one, they could be seen forced to proclaim their immediate demands of Cuba so as not to alienate a single voter," Castro wrote.
Shami Chakrabarti in Derbyshire Times
But Liberty director Shami Chakrabarti said: "Stop and search is one tool of policing but use it as a bludgeon not a rapier and you alienate far more people than you protect. Formal complaints about stop-and-search are inevitably the tip of the...