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• n  a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA)

• Different individuals have slightly different versions of this gene, varying by a single nucleotide (or letter in the DNA alphabet).
• The full 77-nucleotide synthetic yeast gene had been five years in the making.
• The two variants or differences in a single nucleotide exist in about 34% of the population and occur in genes in the same region of the long arm of chromosome 15.

• base

News & Articles

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• Newly identified markers may predict who will respond to breast cancer prevention therapy
  ( American Association for Cancer Research ) Genetic variations, known as single nucleotide polymorphisms, in or near the genes ZNF423 and CTSO were associated with breast cancer risk among women who underwent prevention therapy with tamoxifen and raloxifene, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.
  June 13, 2013 - EurekAlert!
• Genetics and Pharmacogenetics of Schizophrenia: Recent Progress
  FIGURE 1: MC4R single nucleotide polymorphisms rs489693 genotype and a... FIGURE 2: Dose adjustments according to CYP2D6 phenotypes. The dose re...
  June 11, 2013 - Psychiatric Times
• Gilead Announces U.S. FDA Priority Review Designation for Sofosbuvir for the Treatment of Hepatitis C
  Gilead Sciences, Inc. today announced that the U.S. Food and Drug Administration has granted priority review to the company’s New Drug Application for sofosbuvir, a once-daily oral nucleotide analogue inhibitor for the treatment of chronic hepatitis C virus infection.
  June 7, 2013 - Business Wire via Yahoo! Finance

Quotes

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• Roger Kornberg in EurekAlert (press release)
  In the course of the work, we saw something that had never been noticed before- additional protein density beneath the matching nucleotide,Kornberg said.
• David J. Lipman in Innovations-Report
  David Lipman, Director of the National Center for Biotechnology Information, adds: "Today's nucleotide sequence databases allow researchers to share completed genomes, the genetic make-up of entire ecosystems, and sequences associated with patents....