kinase kinase

Definition(s):

  • (n) an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

Usage(s):

  1. The molecule, mitogen-activated protein kinase, or MAP kinase, is five to 20 percent more prevalent in women with breast cancer than in those without the affliction.
  2. If the creatine kinase level is high in such a woman, she should be advised to have no more children.
  3. Other new drugs, including Tarceva and Iressa, also halt tumor growth by messing with tyrosine kinase.

News

  1. Updated Results of Two Phase 2 Ibrutinib Studies in Patients with Mantle Cell Lymphoma or Diffuse Large B-cell Lymphoma

    SUNNYVALE, Calif., June 16, 2013 /PRNewswire/ -- Pharmacyclics, Inc. (the "Company") (Nasdaq: PCYC) today announced the results of two separate Phase 2 studies suggesting that ibrutinib, an investigational oral Bruton's tyrosine kinase (BTK) inhibitor, showed efficacy when used as a...
    on June 16, 2013     Source: PR Newswire

  2. Research and Markets: Triple Analysis: Apoptosis, Cancer Vaccines and Protein Kinase Inhibitors

    DUBLIN--(BUSINESS WIRE)--Research and Markets (http://www.researchandmarkets.com/research/2cww39/triple_analysis) has announced the addition of the "Triple Analysis: Apoptosis, Cancer Vaccines and Protein Kinase Inhibitors" report to their offering. This triple analysis focuses on cancer drug development strategies by mechanism/target/effect of Apoptosis, Cancer Vaccines and Protein Kinase ...
    on June 14, 2013     Source: Business Wire

  3. Kinexus Launches DrugKiNET KnowledgeBase with 105,000 Experimentally Tested Protein Kinase Drug Interactions

    New open-access website also documents over 250,000 predicted protein kinase drug interactions using proprietary algorithms VANCOUVER, June 12, 2013 /PRNewswire/ - Kinexus Bioinformatics Corporation, a ...
    on June 12, 2013     Source: PR Newswire via Yahoo! Finance

Quotes

  1. "Nobody was sure they wanted a dirty kinase inhibitor like SU11248," Ullrich said.
    on Mar 5, 2010 By: Axel Ullrich Source: BusinessWeek

  2. Dr. Schwartz, in commenting on these results, said: "These exciting laboratory studies show that PhGalpha1, an inhibitor of protein kinase C (PKC), enhances the effect of chemotherapy in human cancer cell lines. They provide a strong rationale for...
    on May 16, 2007 By: Gary Schwartz Source: CNW Telbec (Communiqué de presse)

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ambivalent ambivalent
/æm ˈbɪ və lənt /