trazodone n oral antidepressant (trade name Desyrel) that is a nontricyclic drug used as a sedative Usage(s) Andrea then took at least 40 pills of her mother's trazodone, an antidepressant prescribed to help Jutta sleep. Because it left him so exhausted, Janet--an insurance analyst who divorced Matt's father six years ago--cut trazodone from the mix. Andrea then took at least 40 pills of her mother's trazodone, an antidepressant prescribed to help Jutta sleep. Synonym(s) trazodone hydrochloride Desyrel