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• n  an antagonist for estrogen that is used in the treatment of breast cancer

• TAMOXIFEN Most women treated for breast cancer take tamoxifen to prevent the cancer from recurring, but it seems that for the drug to be most effective, timing is key.
• Most women, especially those at low risk, probably won't go on tamoxifen.
• TAMOXIFEN Although a new class of drugs called aromatase inhibitors shows signs of being even more effective than tamoxifen at treating breast cancer, don't count the old drug out .

• estrogen antagonist

News & Articles

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• Genetic variations may help identify best candidates for preventive breast cancer drugs
  ( Mayo Clinic ) Newly discovered genetic variations may help predict breast cancer risk in women who receive preventive breast cancer therapy with the selective estrogen receptor modulator drugs tamoxifen and raloxifene, a Mayo Clinic-led study has found. The study is published in the journal Cancer Discovery.
  June 13, 2013 - EurekAlert!
• Newly identified markers may predict who will respond to breast cancer prevention therapy
  ( American Association for Cancer Research ) Genetic variations, known as single nucleotide polymorphisms, in or near the genes ZNF423 and CTSO were associated with breast cancer risk among women who underwent prevention therapy with tamoxifen and raloxifene, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.
  June 13, 2013 - EurekAlert!

Quotes

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• David Lane in Business Wire (press release)
  Tamoxifen has been a huge success story helping to prevent breast cancer recurring for many women,added Lane. "Understanding why it occasionally stops working is really important because it allows us to identify new targets for drug...
• Bruce Downey in FDA news (subscription)
  We have always believed that our patent challenge settlement related to tamoxifen citrate was pro-consumer and pro-competitive, and this has now been definitively confirmed by the courts,Barr CEO Bruce Downey said.
• V Craig Jordan in Forbes
  For example, Jordan said, "if 100 women had advanced breast cancer, 20 would have estrogen-receptor negative [cancer], and tamoxifen would not be indicated. Eight would be estrogen receptor or ER positive, and 40 would get an initial response from...