prepuberty n a period of two years immediately prior to the onset of puberty when growth and changes leading to sexual maturity occur Usage(s) Prince of Prepuberty Paul Reubens acts like a grownup "Pee-wee Herman is the prince of prepuberty. Disturbed enough by prepuberty engagements, the delegates were shocked at the Guinea custom. This is doneusually as a part of prepuberty or premarital ritesfor reasons varying from esthetics to the desire to reduce female sensuality.