imipramine :

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  • n  a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression

  • As other feel-good pills followedTofranil (imipramine) for depression, Miltown and Equanil (meprobamate) for psychosis, Valium (diazepam) for severe anxiety and lithium for .
  • By tinkering with the chemical structure of antihistamines, a Swiss psychiatrist, Ronald Kuhn, created a drug called imipramine, first of the so-called tricyclic antidepressants.
  • With the introduction of strikingly effective antipsychotic drugs such as chlorpromazine and imipramine in the 1950s, the popularity of shock treatment began to wane.
News & Articles

  • Hiding in Plain Sight: Finding New Targets for Old Drugs
    In late 2011, mice with lung cancer had their tumors reduced by an anti­depressant called imipramine. The basis of the study was the idea that the cancer switches certain genes on, while imipramine turns the same genes off. A neat ...        
    Nov. 14, 2013 - Wired News

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