bacitracin n a polypeptide antibiotic of known chemical structure effective against several types of Gram-positive organisms; usually applied locally Usage(s) A plastic adhesive bandage impregnated with streptomycin, polymyxin and bacitracin is being test-marketed by Multibiotics Corp. By large, they report, any two of four antibiotics in Group Ipenicillin, streptomycin, bacitracin and neomycinwork well together. Meanwhile, another group of doctors tried neomycin combined with bacitracin on babies.