imipramine imipramine


  • (n) a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression


  1. With the introduction of strikingly effective antipsychotic drugs such as chlorpromazine and imipramine in the 1950s, the popularity of shock treatment began to wane.
  2. By tinkering with the chemical structure of antihistamines, a Swiss psychiatrist, Ronald Kuhn, created a drug called imipramine, first of the so-called tricyclic antidepressants.
  3. The study included a control group of patients who received placebos instead of imipramine, along with verbal support and encouragement by psychiatrists.


  • Hiding in Plain Sight: Finding New Targets for Old Drugs

    In late 2011, mice with lung cancer had their tumors reduced by an anti­depressant called imipramine. The basis of the study was the idea that the cancer switches certain genes on, while imipramine turns the same genes off. A neat ...        
    on November 14, 2013     Source: Wired News

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