Mechanism underlying cisplatin-induced ototoxicity ( Neural Regeneration Research ) Studies have shown that calpain participates in gentamicin-, neomycin- and kanamycin-induced inner ear cell apoptosis. Cisplatin has been shown to be an anticancer drug. However, cisplatin can lead to severe ototoxicity, induce cochlear cell apoptosis, and result in hearing decrease or loss, which limits the application of cisplatin in a clinical setting to a ...
Aug. 7, 2013 - EurekAlert!