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• n  a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)

• One potential drawback to blocking gamma secretase is that no one is quite sure what its natural role in the body might be.
• Over the past five years, an explosion of insights into the genetics of Alzheimer's has bolstered confidence that gamma secretase and a related enzyme called beta secretase are not .
• Beta secretase, the gene for which was cloned only in 1999, also provides drug designers with a target.

News & Articles

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• Eli Lilly & Co Halts Alzheimer's Drug Trial
  Lee Rannals for redOrbit.com - Your Universe Online Eli Lilly & Co has ended a clinical trial for an Alzheimer's disease drug during the middle of the study after patients showed abnormal liver biochemical tests. The company announced last week that it would be putting a halt to its LY2886721 drug trial. LY2886721, the code-name for the drug, was designed to inhibit beta secretase , which ...
  June 17, 2013 - redOrbit
• Lilly Voluntarily Terminates Phase II Study for LY2886721, a Beta Secretase Inhibitor, Being Investigated as a ...
  INDIANAPOLIS, June 13, 2013 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced it has stopped its Phase II study (BACC) for LY2886721, a beta secretase (BACE) inhibitor being investigated ...
  June 13, 2013 - PR Newswire via Yahoo! Finance
• Lilly halts Alzheimer's drug trial due to liver problems
  By Ransdell Pierson (Reuters) - Eli Lilly and Co. said on Thursday it halted a mid-stage study of an experimental Alzheimer's disease treatment due to potential liver toxicity, the latest setback in the quest to find a treatment that can slow or cure the memory-robbing condition. Lilly said the Phase II study of the drug, LY2886721, from a class known as beta secretase, or BACE, inhibitors, was ...
  June 13, 2013 - Reuters via Yahoo! News