rofecoxib n a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004 Usage(s) In the meantime, doctors note that aspirin does not cancel the effects of other major painkillers, including rofecoxib and acetominophen. In the meantime, doctors note that aspirin does not cancel the effects of other major painkillers, including rofecoxib and acetominophen. Synonym(s) Vioxx