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• n  a gene that disposes normal cells to change into cancerous tumor cells

• The oncogene is located at the precise point where the fragment of chromosome 8 broke off.
• When the investigators looked more closely, they discovered what is known as an oncogene nearby.
• Robert Weinberg, a biology professor at MIT's Whitehead Institute who discovered the first human oncogene, has long been critical of therapeutic approaches based on the Warburg .

• transforming gene

News & Articles

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• New details of natural anticancer mechanism uncovered
  Scientists have identified key triggers of an important cancer-blocking mechanism in cells. Termed “oncogene-induced senescence,” this mechanism can block most cancer types and is commonly experienced when incipient skin cancers turn instead into slow-growing moles.
  June 11, 2013 - Science Daily
• Scientists Uncover New Details of Natural Anticancer Mechanism
  Scientists at The Scripps Research Institute have identified key triggers of an important cancer-blocking mechanism in cells. Termed "oncogene-induced senescence," this mechanism can block most cancer types and is commonly experienced when incipient skin cancers turn instead into slow-growing moles.
  June 11, 2013 - Newswise
• Scripps Research Institute scientists uncover new details of natural anticancer mechanism
  ( Scripps Research Institute ) Scientists at The Scripps Research Institute have identified key triggers of an important cancer-blocking mechanism in cells. Termed "oncogene-induced senescence," this mechanism can block most cancer types and is commonly experienced when incipient skin cancers turn instead into slow-growing moles. Tumors that achieve malignancy often do so by defeating or ...
  June 11, 2013 - EurekAlert!

Quotes

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• Avram Hershko in Science Daily (press release)
  Only recently has it been realized that Skp2 is a very important oncogene,Dr. Hershko explained in an e-mail. "Dr. Pagano's new study reveals how Skp2 itself is eliminated. This knowledge may be used in the future to down-regulate...