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• n  toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis

• Scientists hope their findings will lead to EGCG-based drugs that have fewer side effects than methotrexate, which can cause vomiting and hair loss, among other ills.
• So has the fact that methotrexate, a highly poisonous substance, is of no value against other cancers unless special techniques of administration are used.
• Methotrexate-CFR treatment is begun soon after amputation.

• methotrexate sodium
• amethopterin

News & Articles

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• Biological treatment not superior to conventional therapy for effect on work loss in patients with rheumatoid arthritis
  Treatment with a biological agent was not superior to conventional treatment in terms of the effect on work loss over 21 months in patients with early rheumatoid arthritis (RA) who responded insufficiently to methotrexate, according to a new report.
  July 2, 2013 - Science Daily
• The effect on work loss of different treatments for rheumatoid arthritis
  Treatment with a biological agent was not superior to conventional treatment in terms of the effect on work loss over 21 months in patients with early rheumatoid arthritis who responded insufficiently to methotrexate, according to a report published by JAMA Internal Medicine, a JAMA Network publication.
  July 1, 2013 - EurekAlert!
• Treatments for Rheumatoid Arthritis and Subsequent Work Loss
  Treatment with a biological agent was not superior to conventional treatment in terms of the effect on work loss over 21 months in patients with early rheumatoid arthritis (RA) who responded insufficiently to methotrexate, according to a report published by JAMA Internal Medicine, a JAMA Network publication.
  July 1, 2013 - Newswise