catecholamine n any of a group of chemicals including epinephrine and norepinephrine that are produced in the medulla of the adrenal gland Usage(s) We know that when catecholamine levels are high, there tends to be more platelet aggregation, which makes a heart attack more likely. We know that when catecholamine levels are high, there tends to be more platelet aggregation, which makes a heart attack more likely.