n a variation in circumstances or fortune at different times in your life or in the development of something
the project was subject to the usual vicissitudes of exploratory research
n mutability in life or nature (especially successive alternation from one condition to another)
Twenty years as an educationist, she has seen every vicissitude of the teaching profession, including near mobbing during a students' election.
En route she passes through every Hollywood vicissitude and fashion, from child abuse to blacklisting to Vietnam protests to exercise tapes.
It calls for poise, concentration, vitality and, above all, for a kind of instinctive communion with the camera that comes partly from inner fiber, partly from vicissitude and .
First Listen: Maps, 'Vicissitude' James Chapman's charming songs sound fizzy and bright throughout Vicissitude , Maps' third album, but they also convey his thoughtful reflections on transition and doubt.
July 1, 2013 - NPR
William Shakespeare in Sydney Morning Herald In my shed,Shakespeare says, "one of the discoveries I made was Patrick White and The Tree of Man. It is extraordinary the way he took a marriage through all its vicissitude; most writers don't take on that challenge."