syph n a common venereal disease caused by the treponema pallidum spirochete; symptoms change through progressive stages; can be congenital (transmitted through the placenta) Usage(s) Yeah, it's like your wife promising you a threesome on your birthday and then you find out it's with Rosie O'Donnel and some bag lady with syph. Yeah, it's like your wife promising you a threesome on your birthday and then you find out it's with Rosie O'Donnel and some bag lady with syph. Synonym(s) syphilis pox lues venerea lues