neuroleptic n tranquilizer used to treat psychotic conditions when a calming effect is desired Usage(s) Risperidone, for example, comes with a page of small-print warnings on side effects, such as the potentially fatal neuroleptic malignant syndrome (an acute toxic reaction to the . Synonym(s) major tranquilizer major tranquillizer major tranquilliser antipsychotic drug antipsychotic agent antipsychotic neuroleptic drug neuroleptic agent