ergotamine n an alkaloid derived from ergot that is less toxic than ergot; causes constriction of blood vessels and is used to treat migraine Usage(s) Ergotamine and dihydroergotamine (DHE) are doubly effective. When such simple remedies as aspirin fail, the standard treatment has been shots of ergotamine tartrate (Gynergen). The two doctors recommended injections of ergotamine tartrate as soon as the headache starts.