cox-2 cox-2

Definition(s):

  • (n) an enzyme that makes prostaglandins that cause inflammation and pain and fever

Usage(s):

  • The once high-flying anti-inflammatories known as cox-2 inhibitors nearly crashed and burned in September 2004, when Merck's popular Vioxx was pulled from the market after a study .

News

  • Toward Safer Tx for Arthritis

    The increased risk of heart attack or stroke associated with many arthritis drugs may be avoidable, according to a new international study by researchers at Imperial College London in the UK and published in July 2013 in the journal PLOS ONE . Medications such as Vioxx, diclofenac, ibuprofen and Celebrex achieve pain management by blocking an enzyme called COX-2.
    on July 8, 2013     Source: ThirdAge

Quotes

  1. "Our previous study on COX-2 inhibitors, which included Vioxx and Celebrex, evaluated whether there was an increased risk of heart attack while taking these medications; the answer was: yes for Vioxx," Linda Levesque, the lead author of the new...
    on May 2, 2006 By: René Lévesque Source: Independent

  2. "We'd be open to any new products coming forward, including Cox-2 inhibitors," FDA Commissioner Dr. Andrew von Eschenbach said in an interview with Reuters taped for C-SPAN television.
    on Apr 13, 2007 By: Dr Andrew von Eschenbach Source: Reuters

  3. "Our molecule is a COX-2 inhibitor like Tylenol and Vioxx and other such drugs," notes West.
    on Jan 24, 2007 By: Robert West Source: University of Wisconsin-Madison University Communications

Word of the Day
amalgamation amalgamation
/ə ˌmæl ɡə ˈmeɪ ʃən /